Nasal Cancer Research

We are currently engaged in a number of exciting projects investigating the physiology, pathophysiology, and pathology of the sinuses to find treatment options for chronic sinusitis and nasal cancer research

Different clinical factors associated with Staphylococcus aureus and Pseudomonas aeruginosa in chronic rhinosinusitis.

Zhang Z, Adappa ND, Doghramji LJ, Chiu AG, Cohen NA, Palmer JN.
Int Forum Allergy Rhinol. 2015 Apr 21. doi: 10.1002/alr.21532. PubMed Abstract

Reconstructive challenges in the extended endoscopic transclival approach.

Kamat A, Lee JY, Goldstein GH, Newman JG, Storm PB, Palmer JN, Adappa ND.J Laryngol Otol. 2015 Apr 1:1-5. PubMed Abstract

Corticosteroid Use Does Not Alter Nasal Mucus Glucose in Chronic Rhinosinusitis.

Hatten KM, Palmer JN, Lee RJ, Adappa ND, Kennedy DW, Cohen NA.
Otolaryngol Head Neck Surg. 2015 Mar 27. PubMed Abstract

Biofilm-forming bacteria and quality of life improvement after sinus surgery.

Zhang Z, Adappa ND, Chiu AG, Doghramji LJ, Cohen NA, Palmer JN.
Int Forum Allergy Rhinol. 2015 Mar 12. PubMed Abstract

The expanded endonasal approach for the treatment of intracranial skull base disease in the pediatric population.

Khalili S, Palmer JN, Adappa ND.
Curr Opin Otolaryngol Head Neck Surg. 2015 Feb;23(1):65-70. PubMed Abstract

Phenylthiocarbamide taste sensitivity is associated with sinonasal symptoms in healthy adults.

Farquhar DR, Kovatch KJ, Palmer JN, Shofer FS, Adappa ND, Cohen NA.
Int Forum Allergy Rhinol. 2015 Feb;5(2):111-8. PubMed Abstract

Bacteriology of inverted papilloma.

Kim LY, Cohen NA, Palmer JN, Kennedy DW, Zhang Z, Adappa ND.
Rhinology. 2014 Dec;52(4):366-70. PubMed Abstract

Inverted papilloma of the sphenoid sinus: risk factors for disease recurrence.

Suh JD, Ramakrishnan VR, Thompson CF, Woodworth BA, Adappa ND, Nayak J, Lee JM, Lee JT, Chiu AG, Palmer JN.
Laryngoscope. 2015 Mar;125(3):544-8. PubMed Abstract

Coagulase-negative Staphylococcus culture in chronic rhinosinusitis.

Zhang Z, Adappa ND, Lautenbach E, Chiu AG, Doghramji LJ, Cohen NA, Palmer JN.
Int Forum Allergy Rhinol. 2015 Mar;5(3):204-13. PubMed Abstract

Quality of life improvement from sinus surgery in chronic rhinosinusitis patients with asthma and nasal polyps.

Zhang Z, Adappa ND, Doghramji LJ, Chiu AG, Lautenbach E, Cohen NA, Palmer JN.
Int Forum Allergy Rhinol. 2014 Nov;4(11):885-92. PubMed Abstract

Bitter and sweet taste receptors regulate human upper respiratory innate immunity.

Lee RJ, Kofonow JM, Rosen PL, Siebert AP, Chen B, Doghramji L, Xiong G, Adappa ND, Palmer JN, Kennedy DW, Kreindler JL, Margolskee RF, Cohen NA.
J Clin Invest. 2014 Mar;124(3):1393-405. PubMed Abstract

MR imaging evolution of endoscopic cranial defect reconstructions using nasoseptal flaps and their distinction from neoplasm.

Learned KO, Adappa ND, Lee JY, Newman JG, Palmer JN, Loevner LA.
AJNR Am J Neuroradiol. 2014 Jun;35(6):1182-9. PubMed Abstract

Culture-inappropriate antibiotic therapy decreases quality of life improvement after sinus surgery.

Zhang Z, Palmer JN, Morales KH, Howland TJ, Doghramji LJ, Adappa ND, Chiu AG, Cohen NA, Lautenbach E.
Int Forum Allergy Rhinol. 2014 May;4(5):403-10. PubMed Abstract

The effect of diabetes mellitus on chronic rhinosinusitis and sinus surgery outcome.

Zhang Z, Adappa ND, Lautenbach E, Chiu AG, Doghramji L, Howland TJ, Cohen NA, Palmer JN.
Int Forum Allergy Rhinol. 2014 Apr;4(4):315-20. PubMed Abstract

Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas.

Brastianos PK, Taylor-Weiner A, Manley PE, Jones RT, Dias-Santagata D, Thorner AR, Lawrence MS, Rodriguez FJ, Bernardo LA, Schubert L, Sunkavalli A, Shillingford N, Calicchio ML, Lidov HG, Taha H, Martinez-Lage M, Santi M, Storm PB, Lee JY, Palmer JN, Adappa ND, Scott RM, Dunn IF, Laws ER Jr, Stewart C, Ligon KL, Hoang MP, Van Hummelen P, Hahn WC, Louis DN, Resnick AC, Kieran MW, Getz G, Santagata S.
Nat Genet. 2014 Feb;46(2):161-5. PubMed Abstract

The bitter taste receptor T2R38 is an independent risk factor for chronic rhinosinusitis requiring sinus surgery.

Adappa ND, Zhang Z, Palmer JN, Kennedy DW, Doghramji L, Lysenko A, Reed DR, Scott T, Zhao NW, Owens D, Lee RJ, Cohen NA.
Int Forum Allergy Rhinol. 2014 Jan;4(1):3-7. PubMed Abstract

A catecholamine-secreting skull base sinonasal paraganglioma presenting with labile hypertension in a patient with previously undiagnosed genetic mutation.

Hahn S, Palmer JN, Adappa ND.
J Neurol Surg Rep. 2012 Oct;73(1):19-24. PubMed Abstract

Vasoactive intestinal peptide regulates sinonasal mucociliary clearance and synergizes with histamine in stimulating sinonasal fluid secretion.

Lee RJ, Chen B, Doghramji L, Adappa ND, Palmer JN, Kennedy DW, Cohen NA.
FASEB J. 2013 Dec;27(12):5094-103. PubMed Abstract

Suprasellar pediatric craniopharyngioma resection via endonasal endoscopic approach.

Ali ZS, Lang SS, Kamat AR, Adappa ND, Palmer JN, Storm PB, Lee JY.
Childs Nerv Syst. 2013 Nov;29(11):2065-70. PubMed Abstract

Isolated sinonasal posttransplantation lymphoproliferative disorder: a clinical and radiographic invasive fungal sinusitis look-a-like.

Hatten KM, Loevner LA, Palmer JN, Adappa ND.
ORL J Otorhinolaryngol Relat Spec. 2012;74(6):339-42. PubMed Abstract

Genetics of the taste receptor T2R38 correlates with chronic rhinosinusitis necessitating surgical intervention.

Adappa ND, Howland TJ, Palmer JN, Kennedy DW, Doghramji L, Lysenko A, Reed DR, Lee RJ, Cohen NA.
Int Forum Allergy Rhinol. 2013 Mar;3(3):184-7. PubMed Abstract

MR imaging evaluation of endoscopic cranial base reconstruction with pedicled nasoseptal flap following endoscopic endonasal skull base surgery.

Learned KO, Adappa ND, Loevner LA, Palmer JN, Newman JG, Lee JY.
Eur J Radiol. 2013 Mar;82(3):544-51. PubMed Abstract

Endoscopic versus open resection of tuberculum sellae meningiomas: a decision analysis.

Bohman LE, Stein SC, Newman JG, Palmer JN, Adappa ND, Khan A, Sitterley TT, Chang D, Lee JY.
ORL J Otorhinolaryngol Relat Spec. 2012;74(5):255-63. PubMed Abstract

T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection.

Lee RJ, Xiong G, Kofonow JM, Chen B, Lysenko A, Jiang P, Abraham V, Doghramji L, Adappa ND, Palmer JN, Kennedy DW, Beauchamp GK, Doulias PT, Ischiropoulos H, Kreindler JL, Reed DR, Cohen NA.
J Clin Invest. 2012 Nov;122(11):4145-59. PubMed Abstract

Endoscopic, endonasal, transclival resection of a pontine cavernoma: case report.

Sanborn MR, Kramarz MJ, Storm PB, Adappa ND, Palmer JN, Lee JY.
Neurosurgery. 2012 Sep;71(1 Suppl Operative):198-203. PubMed Abstract

Radiographic enhancement of the nasoseptal flap does not predict postoperative cerebrospinal fluid leaks in endoscopic skull base reconstruction.

Adappa ND, Learned KO, Palmer JN, Newman JG, Lee JY.
Laryngoscope. 2012 Jun;122(6):1226-34. PubMed Abstract

Nasal irrigation with or without drugs: the evidence.

Adappa ND, Wei CC, Palmer JN.
Curr Opin Otolaryngol Head Neck Surg. 2012 Feb;20(1):53-7. PubMed Abstract

Olfactory groove meningioma.

Adappa ND, Lee JY, Chiu AG, Palmer JN.
Otolaryngol Clin North Am. 2011 Aug;44(4):965-80, ix. PubMed Abstract